There is a growing body of information about hormones, which regulate the appetite. This base of information suggests that various hormones are secreted with eating. In normal or thin subjects, the amount of hormones produced is directly related to the amount of food ingested. These hormones are supposed to suppress the appetite. Thus, the more food eaten, the more hormones released, and the more the appetite is decreased.
A number of hormones have been identified, which may act in this system. The group includes a gut hormone, called GLP1, a hormone from the pancreas called amylin, and a hormone made by fat cells, known as leptin. All three hormones reduce the appetite in various experimental models, in both humans and animals.
Heavy people may have defects in the secretion or action of these hormones. The secretion of GLP1 and amylin may be inadequate. Leptin secretion is actually increased in heavy people; however, its ability to penetrate the brain and affect the appetite center may be decreased.
New approaches to treatment of obesity with existing drugs and new drug development both offer optimism about more successful treatment of obesity in the future. There may be less negative judgment about patients in this area of therapy.
This site is the diabetes portal for Endocrine Consultants, PC. Here our patients and friends can find timely news stories on diabetes, resources for managing diabetes, and dates of upcoming events in the Columbus, Georgia areas. Patients may schedule appointments, send questions, and report blood sugars from this site.
Using This Site:
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